быстрая доставка ~4 недели
Размер
- 100 μL
- 200 μL
- 50 μL
SOCS1 Rabbit mAb (A20838)
- Описание
- Характеристики
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Overview
Product name SOCS1 Rabbit mAb Catalog No. A20838 Host species Rabbit Purification method Affinity purification Isotype IgG CloneNo. ARC51459 Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.Immunogen information
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). Sequence MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGT Gene ID Swiss Prot Synonyms JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1 Calculated MW 24kDa Observed MW Refer to figures Applications
Reactivity Human, Mouse, Rat Tested applications IHC-P IF/ICC Recommended dilution - IHC-P 1:50 - 1:200
- IF/ICC 1:50 - 1:200
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.Key application Immunohistochemistry Immunofluorescence Positive samples Cellular location Cytoplasmic vesicle, Nucleus 
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using SOCS1 Rabbit mAb (A20838) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Immunohistochemistry analysis of paraffin-embedded human colon using SOCS1 Rabbit mAb (A20838) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Immunofluorescence analysis of MCF7 cells using SOCS1 Rabbit mAb (A20838) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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Key applications Immunohistochemistry, Immunofluorescence Host species Кролик Antibody type Primary Antibodies Reactivity Человек, Мышь, Крыса Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). Isotype IgG