быстрая доставка ~4 недели
Размер
- 100 μg
- 1000 μg
- 200 μg
- 500 μg
Rabbit anti-Human IL-10 mAb (CAP) (RM17643)
- Описание
- Характеристики
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Overview
Product name Rabbit anti-Human IL-10 mAb (CAP) Catalog No. RM17643 Catagory Elisa Antibody Kit Application multiplex assay Description Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3.In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators.Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha.Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). Immunogen Recombinant Human IL-10 Protein
Ser19-Asn178
Accession #P22301Purirty Affinity purification Ig Type Rabbit IgG Formulation Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1, PH 7.4. CrossReactivity No cross-reactivity in multiplex assay with recombinant
rIL-10, , mIL-10Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative:0.1%Braveds MB-1 Avoid repeated freeze-thaw cycles.
Application
Recommended
ConcentrationSample ELISA Capture 10ug/106 Rabbit anti-Human IL-10 mAb (CAP)(Cat. No. RM17643) ELISA Detection 0.5-2ug/mL Rabbit anti-Human IL-10 mAb (DET)(Cat. No. RM17644) Standard 1.4-1000pg/mL Recombinant IL-10 Protein (Cat. No. RM94521) Rabbit anti-Human IL-10 mAb (CAP) images
This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
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Antibody type Matched antibody pairs Immunogen Recombinant Human IL-10 ProteinSer19-Asn178Accession #P22301
