быстрая доставка ~4 недели
Размер
- 100 μL
- 200 μL
- 50 μL
Phospho-c-Myc-S373 Rabbit pAb (AP0132)
- Описание
- Характеристики
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Overview
Product name Phospho-c-Myc-S373 Rabbit pAb Catalog No. AP0132 Host species Rabbit Purification method Affinity purification Isotype IgG Background
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.Immunogen information
Immunogen A phospho specific peptide corresponding to residues surrounding S373 of human c-Myc Sequence Email for sequence Gene ID Swiss Prot Synonyms MRTL; MYCC; c-Myc; bHLHe39 Calculated MW 51kDa Observed MW 60kDa Applications
Reactivity Human Tested applications WB Recommended dilution - WB 1:500 - 1:1000
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Key application Western blotting Positive samples A-431 Cellular location Nucleus, nucleolus, nucleoplasm 
Western blot analysis of extracts from A431 cells using Phospho-c-Myc-S373 antibody (AP0132).
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% BSA. -
Key applications Western blotting Host species Кролик Antibody type Primary Antibodies Reactivity Человек Immunogen A phospho specific peptide corresponding to residues surrounding S373 of human c-Myc Isotype IgG