быстрая доставка ~4 недели
Размер
- 100 μL
- 200 μL
- 50 μL
ACVRL1 Rabbit pAb (A1791)
- Описание
- Характеристики
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Overview
Product name ACVRL1 Rabbit pAb Catalog No. A1791 Host species Rabbit Purification method Affinity purification Isotype IgG Background
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.Immunogen information
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human ACVRL1 (NP_001070869.1). Sequence RDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ Gene ID Swiss Prot Synonyms HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1 Calculated MW 56kDa Observed MW 65kDa Applications
Reactivity Human, Mouse, Rat Tested applications WB Recommended dilution - WB 1:500 - 1:2000
Storage buffer Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.Key application Western blotting Positive samples SH-SY5Y, HL-60, MCF7, Jurkat, Mouse lung, Mouse heart, Mouse liver, Rat brain Cellular location Membrane, Single-pass type I membrane protein Customer validation WB(Homo sapiens)
Western blot analysis of extracts of various cell lines, using ACVRL1 antibody (A1791) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s. -
Key applications Western blotting Host species Кролик Antibody type Primary Antibodies Reactivity Человек, Мышь, Крыса Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human ACVRL1 (NP_001070869.1). Isotype IgG