Артикул
GB6003
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AKT
- Описание
-
Product Information
Description
AKT rabbit polyclonal
Protein full name
v-akt murine thymoma viral oncogene homolog 1
Synonyms
AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA,AKT serine/threonine kinase 1
Immunogen
Recombinant protein corresponding to Human AKT
Isotype
IgG
Purity
Affinity purification
Predicted MW.
56 kDa
Observed MW.
60 kDa
Uniprot ID
Applications
applications
species
dilution
positive tissue
WB
Human, Mouse, Rat
1: 1000-1: 2000
Jurkat, MCF7, HT29, HCT116, SW480, lung
Background
RAC-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases. It is commonly referred to as PKB, or by both names as "Akt/PKB". The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Images
Western blot analysis of AKT (GB13427)
at dilution of 1: 1000
Lane 1: Jurkat cell lysate
Lane 2: MCF7 cell lysate
Lane 3: HT29 cell lysate
Lane 4: HCT116 cell lysate
Lane 5: SW480 cell lysate
Lane 6: Mouse lung tissue lysate
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.