Артикул
GB113399
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Anti -Activin Receptor Type IA Rabbit pAb
- Описание
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Product Information
Description
Activin Receptor Type IA rabbit polyclonal
Protein full name
Activin receptor type-1
Synonyms
Activin A receptor type I, Activin A receptor type II like kinase 2, Activin receptor type-1, Activin receptor-like kinase 2, ACTR-I, ACTRI, Acvr1, ACVRLK2, FOP, TSRI, SKR1, ALK2, Hydroxyalkyl protein kinase
Immunogen
KLH conjugated Synthetic peptide
corresponding to Mouse Acvr1
Isotype
IgG
Purity
Affinity purification
Predicted MW.
57 kDa
Observed MW.
57kDa
Uniprot ID
Applications
Applications
Species
Dilution
Positive Tissue
WB
Mouse, Rat
1:500-1:1500
heart, liver
Background
ACVR1 (activin receptor type I), also known as ALK2 or ACTRI, is a receptor for activin. It forms a stable complex with type II receptor after ligand binding. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. ACVR1 is expressed in many tissues including skeletal muscle and chondrocytes. It functions as a receptor for bone morphogenetic protein (BMP) and induces Indian hedgehog in chondrocytes during skeletal development.
Images
Western blot analysis of Acvr1 (GB113399)
at dilution of 1: 1500
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.