Артикул
GB11265
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Anti - ROCK1 Rabbit pAb
- Описание
-
Product Information
Description
ROCK1 rabbit polyclonal
Protein full name
Rho-associated protein kinase 1
Synonyms
P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1, Rock1
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse ROCK1
Isotype
IgG
Purity
Affinity purification
Subcellular location
Golgi apparatus membrane,Cytoplasm,
Cell projection
Uniprot ID
P70335,Q63644
Applications
Applications
Species
Dilution
Positive Tissue
IHC
Mouse, Rat
1: 100-1: 400
spleen, kidney
IF
Mouse, Rat
1: 100-1: 400
spleen, kidney
Background
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation.Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
Images
Immunohistochemistry analysis of paraffin-embedded rat kidney using ROCK1 (GB11265) at dilution of 1: 300
Immunohistochemistry analysis of paraffin-embedded rat spleen using ROCK1(GB11265) at dilution of 1: 300
Immunohistochemistry analysis of paraffin-embedded mouse kidney using ROCK1 (GB11265) at dilution of 1: 300
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.