Артикул
GB111427
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Anti -2B4 Rabbit pAb
- Описание
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Product Information
Description
2B4 rabbit polyclonal antibody
Protein full name
Natural killer cell receptor 2B4
Synonyms
NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2b4,Nmrk
Immunogen
Recombinant protein corresponding to Mouse 2B4
Isotype
IgG
Purity
Affinity purification
Predicted MW.
45 kDa
Observed MW.
60 kDa
Uniprot ID
Q9BZW8, Q07763, Q9JLM2
Applications
Applications
Species
Dilution
Positive Sample
WB
Human, Mouse, Rat
1: 500-1: 1000
lung, lymph node, spleen, thymus
Background
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Images
Western blot analysis of CD244 (GB111427) at dilution of 1: 500
Storage
Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.