быстрая доставка ~4 недели
Размер
- 10 μg
- 100 μg
- 20 μg
- 50 μg
- 500 μg
Recombinant Mouse CD8a Protein (RP01512)
- Описание
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Overview
Product name Recombinant Mouse CD8a Protein Catalog No. RP01512 Description Recombinant Mouse CD8a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys28-Tyr196) of mouse CD8 alpha (Accession #NP_001074579.1) fused with a hFc tag at the C-terminus. Purity > 95% by SDS-PAGE. Endotoxin <0.1EU/ug Formulation Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Species Mouse Background
T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.Product information
Synonym CD8A; CD8; Leu2; MAL; p32 Expression Host HEK293 cells Tag C-hFc Swiss-Prot Gene ID Usage guide
Storage Store the lyophilized protein at -20°C to -80°C for 12 months.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.Reconstitution Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. * For research use only. Not for therapeutic or diagnostic purposes.
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